Results
| PMID | 21110202 |
| Gene Name | ESR1 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | ESR1, ESR2 |
| Other associated phenotypes |
Endometriosis |
|
Arch Gynecol Obstet. 2011 Oct;284(4):885-91. doi: 10.1007/s00404-010-1768-7. Epub Juhasz-Boss, Ingolf| Fischer, Claudia| Lattrich, Claus| Skrzypczak, Maciej| Malik, Eduard| Ortmann, Olaf| Treeck, Oliver Department of Obstetrics and Gynecology, University of Regensburg, Landshuterstr. 53, 93053 Regensburg, Germany. ingolf.juhasz-boess@klinik.uni-r.de BACKGROUND: The role of estrogen receptor beta (ERbeta) in pathogenesis of endometriosis remains to be elucidated. In this study, we have examined the expression of the four main ERbeta transcript isoforms in human endometrial tissue in women with or without endometriosis. METHODS: Total RNA was isolated from native endometrial tissue and transcript levels of ERalpha, beta1, beta2, beta4, beta5 were analyzed by means of RT-PCR. We compared the results with regard to menstrual cycle phase as well as to presence or absence of endometriosis. We prospectively harvested the endometrium of ten women without endometriosis (five for each cycle phase) and eight patients with endometriosis (five in the proliferative phase, three in the secretory phase). RESULTS: ERalpha, beta1, beta2, and beta5 transcripts were detected in both cycle phases. During the proliferative phase, healthy women had a significantly higher ERalpha/ERbeta1-ratio than patients with endometriosis. Irrespective of the cycle phase, ERalpha-mRNA level was significantly higher than transcript levels of ERbeta isoforms. CONCLUSIONS: ERalpha, beta1, beta2, and beta5 are expressed in human endometrium. The individual receptors differed in terms of expression strength but there was no relevant change during the cycle. The decreased ERalpha/ERbeta1-ratio in proliferative endometrium of endometriosis patients suggest that ERbeta1 might be involved in the pathogenesis of endometriosis. Further studies should be undertaken to substantiate the role of ERbeta in endometrial pathology. Mesh Terms: Adult| Endometriosis/*metabolism| Endometrium/*metabolism| Estrogen Receptor beta/genetics/*metabolism| Female| Humans| Menstrual Cycle/metabolism| Prospective Studies| Protein Isoforms| RNA, Messenger/analysis| Reverse Transcriptase Polymerase |
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